Our Location

      840 111th Avenue North,
      Suite 5
      Naples, FL 34108

      Bioidentical Hormone Replacement Therapy (BHRT)

      Medically reviewed by Dr. Robert Rubin, MD. Last reviewed August 2026.


      Clinics in Naples and South Tampa, FL

      Dr. Robert Rubin offers BHRT for both men and women at two locations in Florida:

      • Naples — 840 111th Avenue North, Suite 5, Naples, FL 34108 — (239) 977-9220
      • South Tampa — 405 N. Reo St., Suite 162, Tampa, FL 33609 — (813) 499-1440

      BHRT in Naples BHRT in Tampa

      Telemedicine appointments are available for patients across Florida, including the Tampa Bay Area, South Palm Beach, and North Broward.


      What Is Bioidentical Hormone Replacement Therapy?

      Bioidentical Hormone Replacement Therapy (BHRT) is a treatment method used to correct low or imbalanced hormones in both men and women. Bioidentical hormones are derived from plant estrogens — compounds made from yams, flax, and soybeans — that are chemically and molecularly identical to the hormones your body naturally produces. Because they match your body's own hormones exactly, they can be precisely formulated for each patient's individual needs.

      Hormones function as chemical messengers, directing systems throughout the body. When they decline or fall out of balance — whether through natural aging, chronic stress, diet, medications, or underlying medical conditions — the effects extend well beyond sexual health. BHRT stabilizes that imbalance and restores normal function.


      How BHRT Differs from Conventional Hormone Therapy

      Conventional hormone replacement therapies use synthetic hormones that are patented and standardized — the same dose and formulation for every patient regardless of their individual hormone profile. Bioidentical hormones work differently. Because they can be compounded by a pharmacist based on Dr. Rubin's prescription, they can be calibrated to your specific lab results and adjusted over time as your needs change. This precision is what allows BHRT to produce results with fewer side effects than synthetic alternatives.


      How Hormonal Imbalance Affects Your Health

      The consequences of hormonal decline go well beyond the symptoms most people associate with menopause or andropause. Imbalances in estrogen, progesterone, DHEA, testosterone, thyroid hormones, cortisol, and other hormones can contribute to:

      • Hot flashes, night sweats, and other menopause or andropause symptoms
      • Decreased bone density and increased osteoporosis risk
      • Decreased muscle mass and strength
      • Decreased sex drive and limited sexual pleasure
      • Erectile dysfunction
      • Fatigue and disrupted sleep
      • Brain fog, anxiety, irritability, and depression
      • Weight gain and slowed metabolism
      • Hair loss and thinning skin
      • Increased risk of cardiovascular disease and stroke
      • Cognitive decline
      • Joint pain and inflammation

      The connection between hormones and sleep, joint health, and cognitive function is less widely recognized than it should be. BHRT can address insomnia caused by imbalances in cortisol, melatonin, estrogen, and progesterone. It can reduce inflammation contributing to joint pain — particularly when that pain is linked to menopause or andropause — and may help with insulin resistance and adrenal fatigue in appropriate cases.


      Conditions Treated with BHRT

      Dr. Rubin has experience treating a broad range of conditions with bioidentical hormone therapy, including:

      • Hormone imbalance
      • Perimenopause, menopause, and post-menopausal symptoms
      • Andropause (male hormone decline)
      • Erectile dysfunction
      • Reduced libido
      • Mood swings, depression, and anxiety
      • Fatigue and low energy
      • Memory loss and cognitive decline
      • Osteoporosis and bone density loss
      • Weight gain
      • Hair loss
      • Fibromyalgia
      • Hypothyroidism and hyperthyroidism
      • Adrenal fatigue
      • Insulin resistance
      • Cardiovascular disease risk factors
      • Vaginal dryness
      • Dry or thinning skin

      Not all cases are appropriate for BHRT. Erectile dysfunction caused by nerve damage, psychological factors, or prior cancer treatment may not have a hormonal component. A thorough evaluation is always the first step before any treatment is introduced.


      Benefits of BHRT

      Both women and men experience the benefits of bioidentical hormone therapy, which may include:

      • Higher energy levels
      • Increased sex drive and improved sexual function
      • Reduced brain fog, anxiety, irritability, and depression
      • Increased ability to build muscle mass and strength
      • Better sleep
      • Fewer hot flashes and night sweats
      • Improved metabolism and potential weight loss
      • Reduced risk of osteoporosis and restored bone strength
      • Hair regrowth
      • Reduced fluid retention and bloating
      • Enhanced lipid levels
      • Enhanced feelings of overall wellbeing

      BHRT Delivery Methods

      Bioidentical hormones are available in a range of forms. Dr. Rubin will recommend the delivery method best suited to your treatment plan, hormone levels, and lifestyle:


      FAQs

      How long does it take for BHRT to start working?

      Some patients experience mild relief within a few weeks. It typically takes up to three months to appreciate the full effects of hormone therapy.

      How long do the effects of BHRT last?

      The effects can be maintained indefinitely with continued treatment. Regular follow-up consultations are essential to monitor your hormone levels and adjust your protocol as your needs change.

      How many BHRT treatments are needed?

      BHRT is an ongoing treatment, not a one-time intervention. Continued consultations are required to maintain your hormone balance and respond to any returning symptoms.

      What should I expect from a BHRT consultation?

      Dr. Rubin begins with a functional evaluation that includes lab work, a full physical exam, a review of your medical and family history, and a detailed conversation about your symptoms, lifestyle, and health goals. He then reviews the results with you and builds an individualized treatment plan. No two plans are the same.

      How does BHRT fit into a broader treatment plan?

      BHRT is often most effective as one component of a broader functional medicine approach. For example, if hair loss has a hormonal driver, BHRT may be combined with PRP therapy to accelerate regrowth. If weight gain is connected to hormone imbalance, BHRT may work alongside a medical weight loss program. Dr. Rubin uses every relevant tool to arrive at lasting results rather than treating symptoms in isolation.


      About Dr. Robert Rubin, MD

      Dr. Robert Rubin, MD

      Dr. Rubin is ABIM Board Certified in Internal Medicine and Geriatrics Medicine and an Advanced Fellow in the American Academy of Anti-Aging Medicine. He spent the first 25 years of his career in internal and geriatric medicine, earning recognition from Castle Connolly Medical as one of the "Top Doctors" in South Florida for four consecutive years.

      After completing a fellowship in anti-aging and regenerative medicine, he transitioned fully to functional medicine to better address the unmet needs of patients with chronic and complex conditions. Over the past 15 years, he has built a practice grounded in evidence-based care that takes the time conventional medicine rarely allows.


      Schedule a Consultation

      Free consultations are available at both clinics and via telemedicine for patients anywhere in Florida.

      Naples
      840 111th Avenue North, Suite 5, Naples, FL 34108
      (239) 977-9220
      BHRT in Naples →

      South Tampa
      405 N. Reo St., Suite 162, Tampa, FL 33609
      (813) 499-1440
      BHRT in South Tampa →

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