Medically reviewed by Dr. Robert Rubin, MD. Last reviewed August 2026.
Dr. Robert Rubin offers physician-supervised compounded tirzepatide weight loss programs at two locations in Florida:
Tirzepatide in Naples Tirzepatide in Tampa
Telemedicine appointments are available for patients across Florida, including the Tampa Bay Area, South Palm Beach, and North Broward.
Tirzepatide is the most recently approved medication-assisted weight loss option on the market. A weekly injectable GLP-1/GIP receptor agonist, it was originally developed to treat type 2 diabetes and subsequently received FDA approval for obesity treatment based on its weight loss results in clinical trials — where participants taking the highest dose lost over 20 percent of their starting body weight.
Dr. Rubin uses compounded tirzepatide, which delivers the same clinical effect as brand-name drugs like Mounjaro and Zepbound at a significantly lower cost and without the supply chain disruptions that have affected branded GLP-1 medications. Compounded tirzepatide can also be formulated to your physician's precise specifications, allowing for dose adjustments that standardized brand-name products don't permit.
Tirzepatide's key distinction from other GLP-1 medications is its dual-hormone mechanism. It mimics two naturally occurring hormones rather than one:
The combination of both pathways is what produces tirzepatide's stronger average weight loss results compared to GLP-1-only medications like semaglutide. Patients receive weekly subcutaneous injections, with doses adjusted over time based on their response.
Both tirzepatide and semaglutide are GLP-1 receptor agonists and both are effective medication-assisted weight loss options. The differences come down to mechanism and average outcomes.
Semaglutide activates the GLP-1 pathway only, with clinical studies showing average weight loss of 15–20% of starting body weight. Tirzepatide activates both GLP-1 and GIP, with the highest doses producing average losses exceeding 20% in trials — making it the stronger option for patients who need greater weight reduction or who have not achieved their goals on semaglutide alone.
Dr. Rubin will recommend the appropriate medication based on your evaluation, medical history, and weight loss goals. Some patients begin with semaglutide and transition to tirzepatide; others start with tirzepatide from the outset.
Tirzepatide is the centerpiece of the program, but Dr. Rubin treats it as one component of a broader functional medicine evaluation and personalized plan. Before prescribing anything, he looks for what is actually driving the weight gain — thyroid disease, hormone imbalances, PCOS, medication side effects, insulin resistance, or food sensitivities — and incorporates treatment for those underlying conditions alongside tirzepatide.
Depending on your evaluation results, the program may also include:
Clinical trials showed that patients taking the highest dose of tirzepatide lost over 20% of their starting body weight on average. Individual results depend on starting weight, dose, duration, adherence, and any additional components of your treatment plan.
Weekly subcutaneous injections, self-administered. Dr. Rubin will walk you through the process and titrate your dose upward gradually based on your tolerance and response.
Most patients notice reduced appetite within the first two to four weeks. Meaningful changes in body weight typically become visible over three to six months of consistent treatment.
It depends on the patient. Tirzepatide's dual GLP-1/GIP mechanism produces stronger average weight loss results in clinical trials. For patients who need more significant weight reduction or who haven't responded adequately to semaglutide, tirzepatide is generally the stronger option. Dr. Rubin will recommend the appropriate medication after evaluating your history and goals.
Compounded tirzepatide delivers the same active ingredient at a substantially lower cost, without the supply chain issues that have affected branded GLP-1 drugs. It also allows for dose customization that standardized brand-name products do not permit.
Yes. Tirzepatide consultations and ongoing program management are available via telemedicine for patients anywhere in Florida.
Dr. Rubin is ABIM Board Certified in Internal Medicine and Geriatrics Medicine and an Advanced Fellow in the American Academy of Anti-Aging Medicine. He spent the first 25 years of his career in internal and geriatric medicine, earning recognition from Castle Connolly Medical as one of the "Top Doctors" in South Florida for four consecutive years.
After completing a fellowship in anti-aging and regenerative medicine, he transitioned fully to functional medicine to better address the unmet needs of patients with chronic and complex conditions. Over the past 15 years, he has built a practice grounded in evidence-based care that takes the time conventional medicine rarely allows.
Free consultations are available at both clinics and via telemedicine for patients anywhere in Florida.
Naples
840 111th Avenue North, Suite 5, Naples, FL 34108
(239) 977-9220
Tirzepatide Weight Loss in Naples →
South Tampa
405 N. Reo St., Suite 162, Tampa, FL 33609
(813) 499-1440
Tirzepatide Weight Loss in South Tampa →
