Medically reviewed by Dr. Robert Rubin, MD. Last reviewed August 2026.
Dr. Robert Rubin offers NAD+ Therapy at two locations in Florida:
NAD+ Therapy in Naples NAD+ Therapy in Tampa
Telemedicine appointments are available for patients across Florida, including the Tampa Bay Area, South Palm Beach, and North Broward.
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme present in every living cell. It converts food into energy and plays a central role in metabolism, brain function, DNA repair, immune response, and longevity. It is not a classic nutrient like a vitamin or mineral — it is a vital coenzyme produced from B-vitamin precursors like niacin.
NAD+ levels decline naturally with age, and that decline has been linked to neurodegeneration, metabolic disease, and cancer. Replenishing NAD+ levels may activate sirtuins — proteins associated with longevity and DNA repair — to support cellular regeneration and slow specific aspects of the aging process. Research in this area has made one thing increasingly clear: aging doesn't only move in one direction. Certain interventions can slow or reverse it, and NAD+ therapy is one of the more compelling tools in that category.
NAD+ Therapy is quick-acting. Increased energy and sharper focus are often felt within hours of the first treatment. Other benefits build over weeks to months with consistent therapy:
NAD+ Therapy can also be combined with other targeted nutrients to further support body composition, skin health, mood, and sleep — customized to your specific health goals.
NAD+ Therapy may be used to address:
Dr. Rubin uses subcutaneous (SubQ) injections as his preferred delivery method. SubQ injections bypass the digestive system entirely, delivering NAD+ directly to the bloodstream for maximum absorption and immediate cellular availability. This avoids the side effects — nausea, flushing, chest pressure — that can occur with higher-dose IV therapy, and it can be self-administered in the privacy and comfort of your home.
Other delivery methods exist, including intramuscular (IM) injections, liposomal oral supplements, sublingual sprays, and inhalation delivery. Dr. Rubin will discuss the appropriate method for your situation during your consultation.
Noticeable benefits like increased energy and focus typically start within hours to days of the first treatment. Other benefits — improved body composition, deeper sleep, better mood — continue to build over weeks to months with consistent therapy.
Effects typically last up to two weeks per treatment, though this varies considerably based on metabolism, overall health, age, activity level (more active individuals burn through NAD+ faster), dosage, and frequency. Most patients follow a loading phase followed by regular maintenance doses to sustain results.
Treatment frequency depends on your individual health goals and how your body responds. Dr. Rubin will discuss a schedule during your consultation and adjust it based on your results over time.
NAD+ Therapy delivered via SubQ injection is safe and non-toxic. It is a minimally invasive, non-surgical treatment with a well-established safety profile when administered under physician supervision.
Dr. Rubin is ABIM Board Certified in Internal Medicine and Geriatrics Medicine and an Advanced Fellow in the American Academy of Anti-Aging Medicine. He spent the first 25 years of his career in internal and geriatric medicine, earning recognition from Castle Connolly Medical as one of the "Top Doctors" in South Florida for four consecutive years.
After completing a fellowship in anti-aging and regenerative medicine, he transitioned fully to functional medicine to better address the unmet needs of patients with chronic and complex conditions. Over the past 15 years, he has built a practice grounded in evidence-based care that takes the time conventional medicine rarely allows.
Free consultations are available at both clinics and via telemedicine for patients anywhere in Florida.
Naples
840 111th Avenue North, Suite 5, Naples, FL 34108
(239) 977-9220
NAD+ Therapy in Naples →
South Tampa
405 N. Reo St., Suite 162, Tampa, FL 33609
(813) 499-1440
NAD+ Therapy in South Tampa →
